CLS 422
Coagulation Rotation Final Examination
Study Guide and Description
Last revised: 8/27/04 9:05:00 AM
The Coagulation examination
consists of 75 multiple choice questions with one best answer. The intent of the examination is to evaluate
the student's understanding of the utilization of various laboratory tests in
the diagnosis of specific diseases, and the student's ability to correlate
clinical with laboratory data. Recognizing
that both the NCA and the ASCP national board examinations are NOT practical
examinations, but rather examinations with multiple choice questions based on
theoretical concepts that form the basis for laboratory testing, this
examination is constructed similarly.
The examination is NOT intended to be a review or test of the procedures
that were performed in the clinical rotation.
It contains questions covering all areas of Coagulation, including the
first year courses, CLS 312 and CLS 322, the clinical year rotation in
Coagulation, and the student’s additional readings within the subject area
covered by the examination.
The following list of topics
covers the content areas found on the examination:
1. Acquired dysprothrombinemias/treatment
of choice
2. Acquired qualitative
platelet disorders/definition
3. Afibrinogenemia/clinical
findings
4. Afibrinogenemia/clinical
symptoms
5. APA (antiphospholipid
antibody syndrome)/laboratory findings
6. Bleeding disorder
screening/laboratory testing
7. Chronic ITP/bone marrow
findings
8. Circulating
Anticoagulants/etiology & function
9. Coagulation Plasma
Factors/definitions
10. Congenital Factor
disorders/definitions
11. Disseminated Intravascular
Coagulation/laboratory & clinical findings
12. Drug induced
thrombocytopenia/etiology
13. Extrinsic Coagulation Cascade/laboratory
findings
14. Factor Deficiencies/clinical
findings
15. Factor VIII:C
synthesis/mechanism
16. Fibrin Degradation
Products/pathways
17. Fibrinogen/normal and
abnormal plasma levels/laboratory interpretation
18. Fibrinolysis/laboratory
findings
19. Glanzmann’s Thrombasthenia/laboratory
findings
20. Glanzmann’s
Thrombasthenia/treatment
21. Glycocalyx/function
22. Hemophilia A
inhibitors/characteristics
23. Hemophilia A/clinical
findings
24. Hemophilia A/clinical
management
25. Hemophilia A/mode of
inheritance
26. Hemostasis/organ systems
involved
27. Heparin cofactor/definition
28. Heparin
therapy/complications
29. Ideopathic Thrombocytopenic
Purpura/clinical manifestations
30. Ineffective
thrombopoiesis/disease associations
31. Isoimmune Neonatal
Thrombocytopenia/etiology
32. Megakaryocytic
Hypoplasia/disease associations
33. Myelopthisic Anemia/laboratory findings
34. Oral anticoagulant
therapy/laboratory findings
35. Paraproteinemias/platelet
abnormalities in
36. Pathways of the Coagulation
Cascade/definition
37. Platelet
aggregation/mechanism
38. Platelet Associated Proteins
(PA) in ITP/definition
39. Platelet
count/interpretation
40. Platelet
Factors/anticoagulant neutralization
41. Platelet Function
Inhibition/drug association
42. Platelet plasma membrane
proteins/specific receptors
43. Platelet Zones/definition
44. Procoagulants/definition
45. Protein S/function
46. Prothrombin Time/laboratory
interpretation
47. Quantitative Platelet
disorders/laboratory tests to detect
48. Storage Pool
disorders/disease associations
49. Storage Pool
disorders/definition
50. Thrombin Time/laboratory
interpretation
51. Thrombocytopenia/Clinical
Findings
52. Thrombotic Thrombocytopenic
purpura/clinical features
53. Transfusion associated
coagulation abnormalities/etiology
54. TTP (thrombotic
thrombocytopenic purpura)/clinical findings
55. Uremia/laboratory findings
56. Uremia/treatment of choice
for correction of hemostatic insufficiency
57. Vascular Disorders/clinical
findings
58. von Willebrand’s
disease/clinical features
59. von Willebrand’s
disease/differential diagnosis from Hemophilia A
60. von Willebrand’s
disease/etiology